胡蒋宁

        教授，博士导师

个人简介

        2018年4月-今，大连工业大学食品学院，教授/博士生导师，营养组组长

        2013年10月-2014年9月，加拿大 University of Saskatchewan，博士后

        2013年9月-2018年3月，南昌大学，食品学院，副教授

        2009年9月-2012年3月，南昌大学，生命科学与食品工程学院，讲师

        2006年9月-2009年7月，韩国 Chungnam National University，Department of Food Science & Technology，博士研究生/博士学位

        2003年9月-2006年7月，吉林农业大学，中药学，硕士研究生/硕士学位

        1999年9月-2003年7月，吉林农业大学，中药学，本科/学士学位

社会兼职

        中国食品科学协会医学食品分会理事，中国农学会特产分会第六届委员会理事，中国营养学会油脂分会理事。

研究方向：

(1)食物资源中活性成分开发与利用：针对糖脂代谢调控及肠道功能紊乱等建立食物资源中功能因子筛选平台，利用多组学技术及分子生物学手段研究活性物质构效分子机制研究，建立功效因子高效制备体系及功效评价体系；

(2) 功能食品开发与利用：基于精准营养策略，构建具有靶向作用食源性纳米营养递送体系，实现功能因子提质增效，开发高附加值功能食品；

主要成果

        发表学术论文100余篇，其中以以第一及通讯作者Advanced Science、Biomaterials，Chemical Engineering Journal, ACS AMI等期刊发表SCI一区收录论文60余篇。以第一发明人申请国家专利23项，授权10项。获2023年辽宁省自然科学技术成果二等奖（第1完成人）。参与制定团体标准3项（第一完成成人1项）。国家“十四五”、“十三五”重点研发计划项目课题负责人，入选辽宁省“兴辽英才计划”，辽宁省“百千万人才工程”，江西省“井冈之星”青年科学家培养对象。曾获得了由美国油脂化学协会（AOCS）为纪念AOCS成立100周年颁发的“Certificate of Merit”奖；获得韩国食品协会举第四届国际功能食品会议International Conference on Food Factors “Travel Grant Award奖项”。

科研项目

        参与国家、省、市纵向和横向科研项目多项，主持科研项目20余项，其中国家级项目5项。主持的科研项目如下：
1. 科技部，国家重点研发计划项目“植物源新食品资源综合挖掘与开发利用研究（2023YFF1104000）”课题“植物源新食品资源加工适用性与提质增效技术（2023YFF1104003）”2023-12至2027-12，395.0万
2. 国家自然科学基金委员会，面上项目，32172208，基于褐藻多酚超分子组装水凝胶构建及其缓解肠道功能紊乱分子机制研究，58万元，2022-01至2025-12，58.0万，主持；
3. 科技部，国家重点研发计划项目“食品中重点危害物质高效识别和确证关键技术研究（2018YFC1602300）”子课题“特殊食品中效应物质的高通量检测方法研发 （2018YFC1602306）”， 2018-12至2021-12，366.0 万，主持；
4. 辽宁省科技厅，辽宁省“兴辽英才计划”项目，XLYC1907145， 蛋白改性及其乳化应用研究，2020-01至2022-12， 50万，主持；
5. 辽宁省科技厅，辽宁省百千万人才资助项目，新型MLCT结构脂肪酶法合成及其减脂功效研究， 2020-01至2022-12，2.0万，主持；  
6. 辽宁省科技厅，辽宁省自然基金，20180550202，豆球蛋白-壳聚糖纳米自组装负载Rh2-O体系构建于功效研究，2019-01至2022-12，5万，主持；
7. 国家自然科学基金委员会，面上项目，31571870，基于量子化学及分子动力学探讨非水相合成OMO型结构脂肪过程中酶催化失活机理及其调控研究。2016-01至2019-12，68.0万,主持;  
8. 国家自然科学基金委员会，地区项目, 31360370,基于“溶酶体-线粒体轴心”理论探讨人参皂苷Rh2脂肪酸酯衍生物诱发H22细胞凋亡机制, 2014-01至2017-12, 46万, 主持 
9. 江西省科技厅，江西省“井冈之星”青年科学家培养对象，20153BCB23027，10万， 2014-01至2017-12 ， 主持；
10. 科技部，国家重点研发计划, 2016YFD040140402,基于大宗油料酶法生产功能性结构脂质绿色制造关键技术及产品开发，2016-07 至2020-09，83万，课题骨干；

出版著作和论文

论著：
1. 十四五国家规划教材《食品化学》，参编；
2. 十三五国家规划教材《食品营养学》，参编；

近三年主要代表论文：
2025年度
1. Shumeng Hu, Runan Zhao, Yixin Yuan, Xinru Tang, Xuesong Chi, Zhicong Wang, Xiaoxiao Zhou, Yingying Zhou, Beiwei Zhu, Jiang-ning Hu*. Macrophage-targeted polyphenol-armored nanoparticles synergistically attenuate colitis by suppressing TLR4/Myd88/NF-κB and modulating gut microbiota. Chemical Engineering Journal,522,167934（2025）
2. Runan Zhao, Tao Chen, Shumeng Hu, Xuesong Chi, Songfeng Yu, Yanfei Li, Wenjun Wang, Beiwei Zhu, Donghong Liu, Jiangning Hu*. Orally administered metal–organic framework nanocubes for sequence-targeted quercetin delivery in colitis alleviation, Chemical Engineering Journal, 507,160373(2025)
3. Tao Shu, Fan Li, Jiangning Hu*, Yu Xu*.Poria cocos Polysaccharide-Modified Selenium Nanoparticles: Structural Characterization, Stability, and In Vitro Antioxidant and Anti-Inflammatory Activity Studies.Foods,14,3555-3577（2025）
4. Zhicong Wang, Yingying Zhou, Lihang Chen, Tao Chen, Yuying Wang, Shanshan Ding, Yinan Du, Jiangning Hu*, Di Wu*. Molecular properties and allergenicity of lectin from Ulva lactuca. Sustainable Food Technology,3, 1841-1852 (2025)
5. Ximei Ye, Tao Chen, Lihang Chen, Di Wu, Yinan Du, Jiang-ning Hu*. Hydrogel-Shielded Ellagic Acid Nanoparticles Prolong Colonic Retention and Mitigate DSS-Induced Colitis via Reactive Oxygen Species Scavenging. Foods, 14，2559-2574(2025)
6. Runan Zhao, Shumeng Hu, Tao Chen, Yangjing Li, Xuesong Chi, Songfeng Yu, Wenjun Wang, Donghong Liu, Beiwei Zhu*, Jiang-Ning Hu*. Innovative delivery strategies for quercetin: A comprehensive review of advances and challenges, Comprehensive Review of Food Science & Food Safety 24,70146 (2025)
7. Fengxian Luo, Xinchuang Wang, Wei Tian, Beiwei Zhu, Jiang-Ning Hu*. Multifunctional CuTax nanozyme-based chitosan edible coatings for fruit preservation. International Journal of Biological Macromolecules, 310,143204(2025)
8. Dan Zhang, Wei Tian, Li-Hang Chen, Tao Chen, Di Wu, Yinan Du, Jiangning Hu*. Synergistic effects of oleanolic acid and curcumin nanoparticles in gastric ulcer prevention. International Journal of Pharmaceutics, 674,125465 (2025)
9. Yangjing Li, Wei Tian, Tao Chen, Yanfei Li, Runan Zhao, Yuxin Li, Xuesong Chi, Di Wu, Yinan Du, Jiangning Hu*. Dual-functional Zn@melanin nanoparticles for enhanced antibacterial activity and prolonged fruit preservation. Food Chemistry, 479,143844,(2025)
10. Yangjing Li, Zhicong Wang, Hanxiong Liu, Tao Chen, Yinan Du, Jiangning Hu, Di Wu*. Controlled ionic-induced self-assembly of phycocyanin: Structure, binding mechanism, and molecular dynamics simulation. Food Chemistry, 477, 143603 (2025)
11. Dan Zhang, Beiwei Zhu, Yu Xu, Fengxian Luo, Tao Chen, Lihang Chen, Xinchuang Wang, Di Wu, Jiang-Ning Hu*. Oleanolic acid-based nanoparticles for the treatment of ulcerative colitis. Nanomedicine, 20,11-14(2025)
12. Wen Jiang, Yu Xu, Xin-Chuang Wang, Di Wu, Yi-Nan Du, Jiang-ning Hu*. A phlorotannin nanoparticle–hydrogel composite for enhanced oral delivery and treatment of ulcerative colitis. Journal of Materials Chemistry B,13,3080-3093(2025)
13. Ximei Ye, Tao Chen, Yinan Du, Runan Zhao, Lihang Chen, Di Wu, Jiangning Hu*. Folic acid-based hydrogels co-assembled with protocatechuic acid for enhanced treatment of inflammatory bowel disease. Colloids and Surfaces B: Biointerfaces,246,114367(2025)
14. Wei Gong, Ting-qi Yang, Tao Chen, Jiang-ning Hu*. Effect of cold plasma treatment on the structure and emulsifying activities of phycocyanin. Journal of Food Engineering ,388,112355(2025)
15. Wei Gong, Ting-qi Yang, Wan-ying He, Yu-xin Li, Jiang-ning Hu*. On-demand removable hydrogel film derived from gallic acid-phycocyanin and polyvinyl alcohol for fruit preservation. Food Chemistry, 463,141404(2025)

2024年度
16. Xuesong Chi, Tao Chen, Fengxian Luo, Runan Zhao, Yangjing Li, Shumeng Hu, Yanfei Li, Wen Jiang, LiHang Chen, Di Wu, Yinan Du, Jiang-ning Hu*. Targeted no-releasing L-arginine-induced hesperetin self-assembled nanoparticles for ulcerative colitis intervention. Acta Biomaterialia ,190,560-578(2024)
17. Xin-Chuang Wang, Yu Xu, Wen Jiang, Feng-Xian Luo, Dan Zhang, Di Wu, Yi-Nan Du, Jiang-Ning Hu*. Dual-layer probiotic encapsulation using metal phenolic network with gellan gum-tamarind gum coating for colitis treatment. International Journal of Biological Macromolecules,280,135759-135759 (2024)
18. Tao Chen, Xuesong Chi, Yangjing Li, Yanfei Li, Runan Zhao, Lihang Chen, Di Wu, Jiang-Ning Hu*. Orally Deliverable Microalgal-Based Carrier with Selenium Nanozymes for Alleviation of Inflammatory Bowel Disease. ACS Applied Materials & Interfaces,16,50212-50228 (2024)
19. Runan Zhao, Shumeng Hu, Zhehao Yang, Tao Chen, Xuesong Chi, Di Wu, Wenjun Wang, Donghong Liu, Beiwei Zhu, Jiangning Hu*. Targeted quercetin delivery nanoplatform via folic acid-functionalized metal-organic framework for alleviating ethanol-induced gastric ulcer. Chemical Engineering Journal,498,155700 (2024)
20. Fengxian Luo, Beiwei Zhu, Xinchuang Wang, Tao Chen, Lihang Chen, Di Wu, Yinan Du, Jiangning Hu*. Taxifolin-iron nanozymes with excellent RONS scavenging ability for alleviating ethanol-induced gastric ulcer. Materials Today Nano,281,00513-100513 (2024)
21. Shumeng Hu, Runan Zhao, Tao Chen, Xuesong Chi, Yangjing Li, Di Wu, Beiwei Zhu*, Jiangning Hu*. Construction of chlorogenic acid nanoparticles for effective alleviation of ulcerative colitis. Food & Function,15, 9085-9099 (2024)
22. Li-Hang Chen, Tao Chen, Ru-Nan Zhao, Di Wu, Yi-Nan Du, Jiang-Ning Hu*. Physical properties and antioxidant activity of curcumin zinc metal-organic frameworks. Food Chemistry,460,140449-140449 (2024)
23. Yuxin Li, Ziqi Hua, Yangjing Li, Tao Chen, Abdulhakeem S. Alamri, Yu Xu, Wei Gong, Yiyang Hou, Majid Alhomrani, Jiangning Hu*. Development of multifunctional chitosan-based composite film loaded with tea polyphenol nanoparticles for strawberry preservation, International Journal of Biological Macromolecules,275,133648 (2024)
24. Yanfei Li, Beiwei Zhu, Tao Chen, Lihang Chen, Di Wu, Xinchuang Wang, Dongmei Li, Wei Li, Yinshi Sun, Jiang-ning Hu*. Glutathione-responsive nanoplatforms trigger gaseous intervention of intestinal inflammation through TLR4/MD2/MyD88/NF-κB/iNOS pathway activation and gut microbiota modulation. Chemical Engineering Journal,493,152849(2024)
25. Yanfei Li, Tao Chen, Lihang Chen, Di Wu, Jiang-ning Hu*. Construction of hyaluronic acid-functionalized magnolol nanoparticles for ulcerative colitis treatment.  International Journal of Biological Macromolecules, 268,131920-131920(2024)
26. Qing Liu, Tao Chen, Lihang Chen, Runan Zhao, Ximei Ye, Xinchuang Wang, Di Wu, Jiang-ning Hu*. High Internal Phase Emulsions Stabilized with Ultrasound-Modified Spirulina Protein for Curcumin Delivery. Foods, 13,1324(2024)
27. Yanfei Li, Tao Chen, Lihang Chen, Runan Zhao, Xinchuang Wang, Di Wu, Jiang-ning Hu*. Construction of diallyltrisulfide nanoparticles for alleviation of ethanol-induced acute gastric injury. International Journal of Pharmaceutics,657,124143-124143 (2024)
28. Ziqi Hua, Yanfei Li, Tao Chen, Di Wu, Yu Xu, Jiang-ning Hu*. Morin-Based Nanoparticles for Regulation of Blood Glucose. ACS Applied Materials & Interfaces ACS Applied Materials & Interfaces, 16,21400-21414(2024)
29. Wei Gong, Wanying He, Yiyang Hou, Yuxin Li, Yuanyuan Hu, Beiwei Zhu, Jiang-ning Hu*. Polyvinyl alcohol-based multifunctional hydrogel film: A novel strategy for food preservation packaging. Food Bioscience, 59,104125(2024)
30. Shumeng Hu, Runan Zhao, Xuesong Chi, Tao Chen, Yangjing Li, Yu Xu, Beiwei Zhu*, Jiang-ning Hu*. Unleashing the power of chlorogenic acid: exploring its potential in nutrition delivery and the food industry. Food & Function,15, 4741-4762 (2024)
31. Yu Xu, Wen Jiang, Xinchuang Wang, Fengxian Luo, Jiang-ning Hu*. Phlorotannin-modified selenium nanoparticles for effective relief of acute liver injury, Applied Materials Today,38,102178(2024)
32. Runan Zhao, Tao Chen, Yanfei Li, Lihang Chen, Yu Xu, Xuesong Chi, Songfeng Yu, Wenjun Wang, Donghong Liu, Beiwei Zhu, Jiang-ning Hu*. Biocompatible hydrophobic cross-linked cyclodextrin-based metal-organic framework as quercetin nanocarrier for enhancing stability and controlled release. Food Chemistry,448,139167 (2024)
33. Yanfei Li, Beiwei Zhu, Tao Chen, Lihang Chen, Di Wu, Jiang-ning Hu*. Construction of Magnolol Nanoparticles for Alleviation of Ethanol-Induced Acute Gastric Injury. Journal of Agricultural and Food Chemistry,72,7933-7942 (2024)
34. Yu Xu, Xinchuang Wang, Wen Jiang, Jiang-ning Hu*. Angelica sinensis polysaccharides modified selenium nanoparticles for effective prevention of acute liver injury. International Journal of Biological Macromolecules, 263,130321(2024)
35. Lihang Chen, Jiang-ning Hu*. Development of nano-delivery systems for loaded bioactive compounds: using molecular dynamics simulations. Critical Reviews in Food Science and Nutrition,65,21-22(2024)

2023年度
36. Shumeng Hu, Runan Zhao, Yu Xu, Zelin Gu, Bei-wei Zhu*, Jiangning Hu*. Orally-Administered Nanomedicine Systems Targeting Colon Inflammation for The Treatment of Inflammatory Bowel Disease: Latest Advances. Journal of Materials Chemistry B,12,13-38(2023)
37. Yu Xu, Xinchuang Wang, Wen Jiang, Lihang Chen, Tao Chen, Di Wu, Jiangning Hu*. Porphyra haitanensis polysaccharide-functionalized selenium nanoparticles for effective alleviation of ulcerative colitis[J]. International Journal of Biological Macromolecules,253,127570( 2023)
38. Huijia Yan, Yanfei Li, Sihui Li, Di Wu, Yu Xu, Jiangning Hu*. Phosphatidylserine-functionalized liposomes-in-microgels for delivering genistein to effectively treat ulcerative colitis. Journal of Materials Chemistry B,11, 10404-10417(2023)
39. Tao Chen, Lihang Chen, Fengxian Luo, Yu Xu, Di Wu, Yanfei Li, Runan Zhao, Ziqi Hua, Jiangning Hu *. Efficient Oral Delivery of Resveratrol-Loaded Cyclodextrin-Metal Organic Framework for Alleviation of Ulcerative Colitis. International Journal of Pharmaceutics. 646,123496 (2023) 
40. Sihui Li, Yanfei Li, Di Wu,Yu Xu, Huijia Yan, Jiang-ning Hu*. Metal-polyphenol microgels for oral delivery of puerarin to alleviate the onset of diabetes. Drug Delivery and Translational Research,14,757-772（2023）
41. Fengxian Luo，Beiwei Zhu，Di Wu，Yu Xu，Tao Chen，Yanfei Li，Jiangning Hu*. Construction of Phlorotannin-Based Nanoparticles for Alleviating Acute Liver Injury. ACS Applied Materials & Interfaces,15, 47338-47349（2023）
42. Haibo Huang, Yiyang Hou, Lihang Chen, Wanying He, Xinchuang Wang, Dan Zhang，Jiangning Hu*. Multifunctional Gallic acid self-assembled hydrogel for alleviation of ethanol-induced acute gastric injury. International Journal of Pharmaceutics. 645, 123372(2023)
43. Yanfei Li, Lihang Chen, Yu Xu, Sihui Li, Huijia Yan, Tao Chen, Ziqi Hua, Di Wu, Runan Zhao, Jiangning Hu*. Helical-like assembly of nateglinide as coating for oral delivery of insulin and their synergistic prevention of diabetes mellitus. Advanced Science,10,2301879 (2023) 
44. Runan Zhao, Beiwei Zhu, Yu Xu, Songfeng Yu, Wenjun Wang, Donghong Liu, Jiangning Hu*. Cyclodextrin-based metal-organic framework materials: Classifications, synthesis strategies and applications in variegated delivery systems. Carbohydrate Polymers, 319, 121198 (2023) 
45. Haibo Huang, Lihang Chen, Yiyang Hou, Wanying He, Xinchuang Wang, Dan Zhang，Jiangning Hu*. Self-assembly of chlorogenic acid into hydrogel for accelerating wound healing. Colloids and Surfaces B: Biointerfaces, 228, 113440 (2023)
46. Wei Gong, Hai-bo Huang, Xin-chuang Wang, Wan-ying He, Yi-yang Hou, Jiang-ning Hu*, Tendon-inspired hybrid hydrogel based on polyvinyl alcohol and gallic acid-lysozyme for promoting wound closure and healing. International Journal of Biological Macromolecules, 247,125583 (2023)
47. Yu Xu, Bei-Wei Zhu, Rong Sun, Xiang Li, Di Wu, and Jiang-Ning Hu*. Colon-Targeting Angelica sinensis Polysaccharide Nanoparticles with Dual Responsiveness for Alleviation of Ulcerative Colitis. ACS Applied Materials & Interfaces, 15, 26298-26315 (2023) 
48. Haibo Huang, Wei Gong, Yiyang Hou, Wanying He, Ran Wang, Xinchuang Wang, Jiangning Hu*. Mucoadhesive hydrogel with anti-gastric acid and sustained release functions for amelioration of DSS-induced ulcerative colitis. Journal of Agricultural and Food Chemistry, 71, 4016-4028 (2023)
49. Wei Gong, Haibo Huang, Xinchuang Wang, Wanying He, Jiangning Hu*. Construction of double network hydrogels using agarose and gallic acid with antibacterial and anti-inflammatory properties for wound healing. International Journal of Biological Macromolecules,227,698-710 (2023)
50. Wei Gong, Hong bin Yao, Tao Chen, Yu Xu, Yuan Fang, Hongyu Zhang, Bowen Li, Jiangning Hu*. Smartphone platform based on gelatin methacryloyl（GelMA）combined with deep learning models for real-time monitoring of food freshness. Talanta, 253,124057 (2023)
51. Wei Gong, Haibo Huang, Xinchuang Wang, Wanying He, Jiangning Hu*. Coassembly of fiber hydrogel with antibacterial activity for wound healing. ACS Biomaterials Science & Engineering,9, 375-387(2023)

在读学生人数

        在读博士研究生8名，硕士研究生12名。

毕业学生人数

        已毕业博士研究生8名，硕士研究生42名。