丁  燕

       副教授/硕导

个人简介：

       2018年10月-现在，大连工业大学，食品学院，副教授

       2022年10月-2023年10月，英国卡迪夫大学，化学院，访问学者

       2017年03月-2019年02月，大连理工常熟研究院有限公司，博士后

       2011年08月-2018年09月，大连工业大学，食品学院，讲师

       2010年02月-2011年01月，韩国忠南国立大学，医药品开发研究所，博士后
       2006年08月-2010年02月，韩国忠南国立大学，药学院，药学博士

       2003年09月-2006年06月，吉林农业大学，中药材学院，医学硕士

       1999年09月-2003年06月，吉林农业大学，中药材学院，理学学士

社会兼职：

研究方向：

       天然产物化学与功能性；食品营养性与健康关系；食品质量控制与安全性

科研项目：

         主持并参与国家、省、市纵向和横向科研项目多项，目前承担的主要科研项目：

       （1）辽宁省科技计划博士启动基金：基于MC3T3-E1、BMMs的细胞水平抗骨质疏松药效评价体系的构建及15种药食两用中药的活性评价（20121097），4万。

       （2）辽宁省教育厅科技研究一般项目：韩茵陈中促进成骨细胞MC3T3-E1分化萜类物质的研究（L2012183），3万。

       （3）教育部留学回国人员科研启动基金：基于MC3T3-E1的莲藕有效成分促进骨形成作用机理研究（教外司留[2013]693号），3万。

       （4）大连市高层次人才项目：基于色谱分析分离平台的中药化学组分、成分库构建关键技术研究（2016RQ064），10万。

       （5）辽宁省教育厅基本科研项目：基于工业色谱装备的天然产物化学分离制备平台的构建（2016J008），10万。

       （6）辽宁省自然科学基金面上项目：基于HPLC-MS技术及化学计量学方法硫磺熏蒸对人参特征成分影响机制研究（2021-MS-299），5万。

       （7）横向课题：3种药茶的质量指标筛选及测试分析研究（中国标准化研究院），20万。

出版著作和论文：

论著：

       1. 《食品感官评价》，参编

       2.  《中国菌物药》，参编

主要代表论文:

       (1) Li Yaxin, Zhou Zheng, Wu Qi, Chen Baoguo, Ye Shuhong, Cui Yuna,Ding Yan*. Untargeted metabolomics combined with vitro antioxidant to comprehensively evaluate the effect of sodium sulfite immersion on the holistic quality of mung bean sprouts. 2024. Journal of Food Science. (SCI, 3.9)

       (2) Li Yaxin, Chen Baoguo, Ye Shuhong, Wu Qi, Zhu Lin,Ding Yan*. Discrimination of untreated and sodium sulfite treated bean sprouts by Fourier transform infrared spectroscopy and chemometrics. 2024. Food Additives & Contaminants: Part A. (SCI, 2.9)

       (3) Chen Baoguo, Li Yaxin, Li Wei, Ye Shuhong, Zhu Lin,Ding Yan*. Antitumor Activity and Mechanism of Terpenoids in Seaweeds Based on Literature Review and Network Pharmacology. Advanced Biology. 2024, 8(3), e2300541.  (SCI, 3.7)

       (4) Chen Jialiang, Zhou Zheng, Li Ping, Ye Shuhong, Li Wei, Li Ming, Zhu Lin,Ding Yan*. Investigation of the Potential Phlorotannins and Mechanism of Six Brown Algae in Treating Type II Diabetes Mellitus Based on Biological Activity, UPLC-QE-MS/MS, and Network Pharmacology. Foods. 2023, 12(16), 3000. (SCI, 5.2)

       (5) Yousuf Sabiha, Liu He, Yingshu Zhang, Zahid Danish, Ghayas Hassan, Li Ming*,Ding Yan*, Li Wei*. Ginsenoside Rg1 modulates intestinal microbiota and supports re-generation of immune cells in dexamethasone-treated mice. Acta microbiologica et immunologica Hungarica. 2022, 69(4), 259-269. (SCI, 2.298)

       (6) Li Ping, Sun Hao, Li Wei, Wu Qi, Ye Shuhong, Zhu Jingbo,Ding Yan*. Isolation and purification of 12 flavonoid glycosides from Ginkgo biloba extract using sephadex LH-20 and preparative high-performance liquid chromatography. Zeitschrift für Naturforschung C. 2022, 78(1-2), 73-81. (SCI. 1.885)

       (7) Chen Jialiang, Li Pin, Ye Shuhong, Li Wei, Li Ming,Ding Yan*. Systems pharmacology-based drug discovery and active mechanism of phlorotannins for type 2 diabetes mellitus by integrating network pharmacology and experimental evaluation. Journal of food biochemistry. 2022, 46(12), e14492. (SCI, 3.6554)

       (8) Li Ping, Zhang Yanna,Ding Yan*, Wu Qi, Liu Zhaofang, Zhao Penghui, Zhao Guojing, Ye Shuhong*. Discrimination of raw and sulfur-fumigated ginseng based on Fourier transform infrared spectroscopy coupled with chemometrics. Microchemical Journal. 2022, 181, 107767. (SCI, 5.304)

       (9) Wang Bin,Ding Yan*, Zhao Penghui, Li Wei, Li Ming, Zhu Jingbo, Ye Shuhong*. Systems pharmacology-based drug discovery and active mechanism of natural products for coronavirus pneumonia (COVID-19): An example using flavonoids. Computers in biology and medicine. 2022, 143, 105241. (SCI, 6.698)

       (10) Wang Fanfan, Ye Shuhong*,Ding Yan*, Ma Zhiyang, Zhao Qike, Zang Min, Li Yue. Research on structure and antioxidant activity of polysaccharides from Ginkgo biloba leaves. Journal of Molecular Structure. 2022, 1252, 132185. (SCI, 3.841)

       (11) 朱靖博*，王琳，丁燕，王振中，萧伟. 二维液相色谱分离制备热毒宁注射液主要成分. 大连工业大学学报. 2021, 40(04): 247-252.

       (12) 王玥，丁燕*，朱靖博. 三七中皂苷类标准物质的规模化制备分离. 大连工业大学学报. 2021, 40(05): 325-328.

       (13) 吴金倩，朱靖博*，丁燕*，肖伟. 补骨脂中化合物系统性分离制备. 天然产物研究与开发. 2020, 32:38-46

       (14) Zhang Yanna, Wang Bin, Zhao Penghui, He Fan, Xiao Wei, Zhu Jingbo,Ding Yan*. A comprehensive evaluation protocol for sulfur fumigation of ginseng using UPLC-Q-TOF-MS/MS and multivariate statistical analysis. LWT: Food science and technology. 2021, 145, 111293 (SCI, 4.006) 

       (15) Wang Fengqi, Zhang Yanna, Wu Qi, Xiao Wei, Zhu Jingbo,Ding Yan*. Purity determination and uncertainty estimation of natural products sourcing chemical reference substances by high-performance liquid chromatography and differential scanning calorimetry. Microchemical journal. 2021, 166, 106257 (SCI, 3.594) 

       (16) Li Yan,Ding Yan*, Xiao Wei, Zhu JingBo*. Investigation on the active ingredient and mechanism ofCannabis SativaL. for treating epilepsy based on network pharmacology technology. Biotechnology & Biotechnological equipment. 2021, 35(1), 994-1009 (SCI, 1.227) 

       (17) Yajie Zhu,Yan Ding*,·Tian Dongxu, Li Yan, Zhuang Linwu, Wang Yinpeng, Xiao Wei, Zhu Jingbo *. Theoretical design and mechanism research of molecularly imprinted polymers for steviol glycosides. Journal of Molecular Modeling. 2021, 8 (on line) (SCI, 1.346) 

       (18) Zhu Jingbo，Cui Weibin，Xiao Wei，Ding Yan*，Huang Wenzhe，Tu Pengfei，Wang Yonghua. Isolation and enrichment of Ginkgo biloba extract by a continuous chromatography system. Journal of Separation Science. 2018, 41: 2432–2440. （SCI, 2.415）

       (19) 朱靖博*，籍立新，肖 伟，丁燕*，黄文哲，屠鹏飞，王永华. 反相二维色谱制备甘草中的黄酮类化合物. 中草药. 2018, 49(9), 2033-2040

       (20) 朱靖博*，李文玉，肖 伟，丁燕*，黄文哲，屠鹏飞，王永华. 反相二维液相色谱制备五味子中的木脂素. 色谱. 2018, 36(5), 464-473.

       (21) 丁燕，王枫琦，张开梅，张立鹏，苍小鑫，杜香琳，朱靖博*，萧伟. 基于QSAR模型的食品谱效关系研究：以植物黄酮为例. 中国食品学报. 2018，18（8）,239-246.（EI）

       (22) 丁燕，张立鹏，王靖，张开梅，王枫琦，萧伟，朱靖博*. 基于微核试验及彗星试验评价丹酚酸A、丹酚酸B及原儿茶醛的抗突变活性. 中国食品学报. 2018,18（9）,311-316.（EI）

       (23) 苍小鑫，赵小明，钟润涛，王文霞，尹恒，朱靖博，丁燕*. 基于液滴微流控的壳寡糖植物免疫诱导剂荧光检测. 农业工程学报. 2017,33(2)：302-307.（EI）

       (24) 徐飞飞，丁燕*，张海东，郭盈莹，曲丹，寇自农，肖伟，朱靖博*，15 种药食同源中 药提取物抗氧化及抗骨质疏松活性研究. 中国食品学报，2017 , 17 (6) :240-248 .（EI）

       (25) 丁燕*，孙浩，徐飞飞，曲丹，王枫琦，萧伟，朱靖博*，基于雌激素靶标的药食同源 中药抗骨质疏松活性网络药理学初探. 中国食品学报，2017, 17(12): 182-192. （EI）

       (26) Xu Fei Fei, Ding Yan*, Guo Ying Ying, Liu Bao Yue, Kou Zi Nong, Xiao Wei, Zhu Jing Bo*, Anti-osteoporosis effect of Epimedium via an estrogen-like mechanism based on a system-level approach. Journal of Ethnopharmacology, 2016, 177: 148-160.（SCI, 2.998）

       (27) Ding Yan, Qu Dan, Zhang Kai-Mei, Cang Xiao-Xin, Kou Zi-Nong, Xiao Wei, Zhu Jing-Bo Phytochemical and biological investigations of Amaryllidaceae alkaloids: a review, Journal of Asian Natural Products Research, 2016 , 19 (1) :53-100（SCI, 1.009）

       (28) Guo Ying Ying, Ding Yan*, Xu Fei Fei, Liu Bao Yue, Kou Zi Nong, Xiao Wei, Zhu Jing Bo*, Systems pharmacology-based drug discovery for marine resources: An example using sea cucumber (Holothurians). Journal of Ethnopharmacology, 2015, 165: 61-72.（SCI, 2.998）

       (29) Ding Yan, Kim Jeong Ah, Yang Seo Young, Kim Won-Ki, Lee Sang Hyun, Jang Hae Dong, Kim Young Ho*, Antioxidative Sesquiterpenes from Artemisia iwayomogi. Bulletin of the Korean Chemical Society, 2011, 32(9): 3493-3496. (SCI, 1.257)

       (30) Ding Yan, Wu En Qi, Liang Chun, Chen Jian bo, Kang Jong Seong, Park Kyung Lae, Bae KiHwan, Kim Young Ho*, Quality evaluation and comparative study of Cinnamomi Ramulus and Cinnamomi Cortex in different countries based on HPLC fingerprintchromatogram and pattern analysis. Food Chemistry, 2011, 127, 755-760. (SCI, 3.146)

       (31) Ding Yan, Liang Chun, Kim Jun Ho, Lee Young-Mi, Hyun Jae-Hee, Kang Hee-Kyoung, Kim Jeong-Ah, Min Byung Sun, Kim Young Ho*, Triterpene compounds isolated from Acer mandshuricum and their anti-inflammatory activity. Bioorganic & Medicinal Chemistry Letters, 2010, 20(5): 1528-1531. (SCI, 2.531)

       (32) Ding Yan, Liang Chun, Nguyen Huu Tung, Choi Eun Mi, Kim Jeong-Ah, Kim Young Ho*, Chemical constituents from Acer mandshuricum and their effects on the function of osteoblastic MC3T3-E1 cells. Bulletin of the Korean Chemical Society, 2010, 31(4): 929-933. (SCI, 1.257) 

       (33) Ding Yan, Liang Chun, Yang Seo Young, Chan Jeong, Choi Eun Mi, Kim Jeong-Ah, Kim Young Ho*, Phenolic compounds from Artemisia iwayomogi and their effects on osteoblastic MC3T3-E1 cells. Biological & Pharmaceutical Bulletin, 2010, 33(8): 1448-1453. (SCI, 1.765) 

       (34) Ding Yan, Liang Chun, Yang Seo Young, Kim Jun Ho, Lee Young Mi, Kim Young Ho*, Iwayoside A, a new Diterpene Glycoside from Artemisia iwayomogi Kitamura that enhances IL-2 Secretion. Bulletin of the Korean Chemical Society, 2010, 31(8): 2422-2423. (SCI, 1.257) 

       (35) Ding Yan, Nguyen Huu Tung, Choi Eun Mi, Bae Kihwan, Kim Young Ho, Rhusonoside A, a new megastigmane glycoside from Rhus sylvestris, increases the function of osteoblastic MC3T3-E1 Cells. Planta medica, 2009, 75(2), 158-62. (SCI, 1.960) 

       (36) Ding Yan, Nguyen Huu Tung, Kim Sung In, Kim Ha Won, Kim Young Ho*, The regulation of inflammatory cytokine secretion in macrophage cell line by the chemical constituents of Rhus sylvestris. Bioorganic & Medicinal Chemistry Letters, 2009, 19(13): 3607-3610. (SCI, 2.531) 

       (37) Ding Yan, Bao Hai Ying, Bau Tolgor, Li Yu, Kim Young Ho*, Antitumor Components from Naematoloma fasciculare. Journal of Microbiology and Biotechnology, 2009, 19(10): 1135-1138. (SCI, 2.32)

       (38) Ding Yan, Liang Chun, Choi Eun Mi, Ra Jeong Chan, Kim Young Ho*, Chemical Constituents from Artemisia iwayomogi Increase the Function of Osteoblastic MC3T3-E1Cells. Natural Product Sciences 2009, 15(4): 192-197. 

       (39) Ding Yan, Wu En Qi, Chen Jianbo, Nguyen Huu Tung, Do Thi Ha, Park Kyung Lae, Bae KiHwan, Kim Young Ho, Kang Jong Seong*, Quality evaluation of Moutan Cortex Radicis using multiple component analysis by High Performance Liquid Chromatography. Bulletin of the Korean Chemical Society, 2009, 30(10): 2240-2244. (SCI, 1.257) 

       (40) Ding Yan, BAO Hai-Ying, BAU Tolgor, LI Yu. Anti-tumor effect of Naematoloma fasciculare polysaccharide. 菌物学报, 2006, 25 (4)：611-615.

       (41) 丁燕, 图力古尔, 包海鹰. 沿丝伞属真菌化学成分与药理学研究概况. 菌物学报, 2004, 23 (4)：605-611.

       (42) 包海鹰, 丁燕, 李登科, 李玉. 胶陀螺发酵液的研究. 菌物研究, 2003，1(1)：40-43.

在读学生人数：

       在读硕士研究生7名。

毕业学生人数：

       已毕业硕士研究生15名。